beta amyloid fibril elongation
(supported by the NIH)

The Center is collaborating with Ron Wetzel’s group at the University of Tennessee Medical Center to resolve structure/function relationships associated with beta amyloid fibril formation.

Biosensor technology is being used to monitor the addition of monomer beta amyloid units to the growing end of the fibril tip. Our previous work on this system has demonstrated the utility of biosensors to provide novel information about the mechanism of fibril growth. Current efforts involve characterizing how mutations within the peptide affect recognition of the growing fibril tip.