General Information
The University of Utah Mass Spectrometry and Proteomics Core Facility provides mass spectrometry services and consultation for the University of Utah and Huntsman Cancer Institute (HCI) research communities, and operates as a fee-for-service resource. The primary focus of the Facility is geared toward supporting proteomics research and improving available mass spectrometry techniques for biomedical investigations; our mission is to provide the highest quality analysis of proteins and other biomolecules.
The Facility is equipped with state-of-the-art proteomics instrumentation, including a new FTMS instrument (LTQ-FT), as well as other high-performance mass spectrometers, to provide a wide range of proteomics services, techniques, and capabilities. The LTQ-FT instrument has extremely high sensitivity for protein ID (attomole-range) and is well equipped with CID, IRMPD, and ECD fragmentation techniques for mapping modifications (e.g. phosphorylation, GlcNAc) and enabling other proteomics applications, such as “top-down” protein analysis. LC/MS/MS instruments are interfaced with nanoLC, for ultimate sensitivity and chromatographic performance.
The MS and Proteomics Core Facility also continues to provide basic mass spectrometry services for the University, as well as biotech companies in the region and other academic institutions. A broad range of research applications are supported and various sample types are accepted for analysis (e.g. natural products, synthetic peptides, small molecules, polymers, PCR products, nucleic acids, and other biomolecules).
