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General MS Services

The MS and Proteomics Core Facility provides basic mass spectrometry services for the University community, as well as biotech companies in the regional area and other academic institutions. A broad range of research applications and sample types are accepted for analysis (e.g. natural products, synthetic peptides, small molecules, polymers, PCR products, nucleic acids, PCR products, and other biomolecules).

ESI and MALDI ionization methods on Quadrupole or Time-of-flight (TOF) instruments are available for sample analyses.

General MS Service What is Performed at the Facility
ESI/MS
(Electrospray Ionization/ Mass Spectrometry)
Positive-ion ESI or negative-ion ESI; sample introduction by infusion
  1. Ziptip purification, if required
  2. ESI/MS analysis
  3. Provide mass spectrum of results as hardcopy or electronic file (if requested)
ESI/MS/MS
(Electrospray Ionization/ Mass Spectrometry/ Mass Spectrometry)
For structure elucidation, confirmation of structure, and determining fragmentation pathways

Positive-ion or negative-ion ESI;
MS/MS with CID; Daughter-ion, Parent-ion, or Neutral-loss analyses available
  1. Ziptip purification, if required
  2. ESI/MS/MS analysis
  3. Provide mass spectrum of results as hardcopy or electronic file (if requested)
Nucleic Acids
DNA oligomers, RNA oligomers, PCR products, other nucleic acids

Negative-ion ESI/MS analysis;
MaxEnt deconvolution of data to generate a neutral molecular-mass spectrum
  1. Precipitation purification, if required
  2. ESI/MS analysis
  3. Provide molecular-mass spectrum using MaxEnt deconvolution; hardcopy of data or electronic file (if requested)
LC/MS
(Liquid Chromatography/ Mass Spectrometry)
Positive-ion ESI; sample introduction by nano-LC or micro-LC
  1. Ziptip purification, if required
  2. LC/MS analysis
  3. Provide hardcopy of data or electronic file (if requested)
MALDI/ ToF
(Matrix-assisted Laser Desorption Ionization/ Time of Flight)
Positive-ion or negative-ion MALDI; linear or reflectron mode
Accurate-mass measurements with internal standard (< 10ppm mass error)
Several matrices available
  1. Ziptip purification, if required
  2. Maldi/ToF analysis (linear or reflectron)
  3. Accurate mass measurement, if requested
  4. Provide hardcopy of data or electronic file (if requested)
Special Project/ Method Development Inquire

Use the links below to learn about specific services:

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